Nine-month post-stem cell follow-up results

I recently saw my longest follow-up stem cell patient at nine months out from stem cell treatment. This 57 yr old medically retired nurse was a KPS of 40 prior to stem cell therapy and an invalid with basic ADL assistance provided by her husband in the three months prior to stem cells given in early February 2009. She was essentially bed or couch bound and quite ill at times. Over the first three months post-transfusion, not much happened except notable hypersomnolence which is typical for post-stem cell CFS cases. Her family noted, however, that she looked and acted as if she felt better but she remained largely couch and bed-bound with limited function.

Beginning at three months she began to improve functionally in a slow linear fashion and by early June attended a family reunion and actually water skied, cooked, cleaned and walked daily for the first time in years. She noted to her husband that she was 95% recovered. In the two months after the reunion, she had a mild relapse attributed in part to her over-extension during the reunion. In the last month she has rebounded and now cooks, shops, engages in some limited hobbies and goes out socially with friends. She does feel limited in choice of activities, in part, because she fears a relapse. I estimate her KPS at 65 as she notes she could live alone and engage in regular hobbies. She could not work a regular part-time job, however.

I though she looked great with glowing, pink skin and seemed alert and very relaxed and rested compared to her gray, haggard look in February. Her exam was largely unremarkable except for slightly increased ankle jerks at 3-4+ and a positive augmented Tandem Stance as in her May visit. She failed to desaturate on breath-old. Her B/P was up to 120/82 c/w 90/60 in January.

On echo she demonstrated continued pseudonormal diastolic dysfunction but with a pretty good cardiac output for her size and a normal IVRT for age at 88 msec. Her ETM was spectacularly improved and is the first CFS case with a normalized pLiver and Fructose backflash. The amplitudes of her only two remaining significant backflashes were 40% improved over May and at low, single digits (3%). Of the seven backflashes the typical CFS ETM shows, she only has three left and one of the three is only 2% while the other two are at 3% which is significantly better than any other patient in the practice by far. Her ETM is both quantitatively and qualitatively improved over May and even better c/w January suggesting the stem cells remain active at nine months out.

She was XMRV antigen negative in May. Antibody status is unknown. TGF Beta 1 was significantly improved in February as were many other tests but we are awaiting a whole list of tests from this visit. MSQ and SF-36 SF are pending but should be significantly improved. She takes Artesunate and Wormwood 5-days per week as part of her protocol. Her favorite medicine is Inosine for its punch and not an uncommon statement in my practice.