Public Relations

I expect that Next Generation Sequencing or NGS, which does not have the flaws of PCR technology in evaluating a poorly understood human virus(es), will be the best way forward to a consensus as to the question of association of CFS with XMRV/HGRV.

GcMAF appears to be an effective therapy for well defined CFS partients

On the 23rd of August 2010, a PNAS on-line publication (Lo et al) was published out of the NIH and the FDA confirming Judy Mikovits’ October 2009 Science papers’ assertion that a Mouse Leukemia Virus (MLV)-related retrovirus (RV) is strongly linked to CFS.

The finding of antibody or active virus in 95% of CFS and 4% of controls is a result that argues for causality, in my opinion, especially with the associated RNAse-L corruption and NK functional impairment that might predict such an infection. This novel retrovirus could easily shift the redox state just like HIV as published in (2001) and (1995) and induce all manner of associated pathogens as seen in CFS,,,,. A redox shift could ultimately corrupt the gut ecology and create P450 decoupling based on NADPH depletion observed in CFS and lead to environmental illness as well. Time will tell but I think Dr. Mikovits is right to suspect causality. I also think this virus is infectious with at least ten million Americans infected who appear healthy and perhaps another four million Americans or more with CFS as recently estimated by the CDC (2007). However, disease expression may be more limited causing the illusion that it is not infectious. Furthermore, there may be other diseases that are similar and dissimilar to CFS that are associated with if not caused by XMRV.

In this post, we explore the incredible finding that different ratios of omega-3 to omega-6 EFA’s appear to produce dramatically different effects on the echocardiographically derived ETM, both positive and negative. Surprisingly, the use of omega-3 EFA’s and especially fish oil is uniformly negative (N=10) in CFS but not in controls (N=3). This is not terribly surprising since omega-3 oils are far more easily oxidized and is possibly explained by the more redox impaired status of CFS. However, we are also finding that omega-6 alone, while better than omega-3 alone in an oxidizing state such as CFS, is not nearly as positive as a mixture of the omega-3, omega-6 and omega-9 EFA’s. In particular, a ratio of omega-6 to omega-3 of 3:1 appears ideal and generates the most positive ETM response. Such a ratio is found in high grade olive oil but not lower grades of olive oil which are as high as 13:1, omega-6 over omega-3.